Endocarditis Prophylaxis
Recently significant changes to the prophylaxis guidelines
have been made with more restricted indications.
Children at risk should establish and maintain the best
possible oral health to reduce potential sources of bacteraemia which includes
tooth brushing and regular dental review.
Dental health for children with heart conditions
Single dose antibiotic prophylaxis is now only recommended
for children with the highest risk of adverse outcome of infective endocarditis
(see Table 1)
In certain individual circumstances, medical and dental
practitioners may consider giving antibiotics to patients not covered by these
revised guidelines including those who have received prophylaxis over their
lifetime. Recommendations for individual
patients should be discussed with the treating cardiologist.
Cardiac Conditions for which endocarditis prophylaxix with
dental procedures is reasonable
Prosthetic cardiac valve or prosthetic valve material used
for cardiac valve repair
Previous episode of infective endocarditis
Congenital heart disease (CHD) but only if it involves:
Unrepaired cyanotic defects, including palliative shunts and
conduits
Repaired congenital heart defect with prosthetic material or
device (surgical or catheter intervention) during the first 6 months after the
procedure
Repaired defects with residual defect at the site or
adjacent to the sire of a prosthetic patch or prosthetic device
Rheumatic heart disease in indigenous Australians
Cardiac transplantation recipients who develop cardiac
valvulopathy
At risk procedures
that require prophylaxis include:
Dental procedures that involve manipulation of gingival
tissue or the periapical region of teeth or perforation of the oral mucosa,
Invasive respiratory procedures (incision or biopsy of
respiratory mucosa - including tonsillectomy and adenoidectomy)
Invasive genitourinary and gastrointestinal procedures.
Incision and drainage of local abscesses
Surgical procedures through infected skin (cellulitus)
Recommended prophylaxis:
amoxicillin 50 mg/kg oral 1 hour before procedure (max. 2 g)
if unable to take oral medication, give amoxicillin/ampicillin
50 mg/kg i.v. at induction (max. 2 g)
If hypersensitive to penicillin, and those on long-term
penicillin therapy or who have taken penicillin pr a related beta lactam
antibiotic more than once in the previous month, use:
clindamycin 600 mg (child: 15 mg/kg up to 600 mg) orally, 1
hour before the procedure
or clindamycin 600 mg (child: 15 mg/kg up to 600 mg) IV over
at least 20 minutes, just before the procedure
OR
lincomycin 600 mg (child: 15 mg/kg up to 600 mg) IV over at
least 1 hour, just before the procedure
OR
vancomycin 25 mg/kg up to 1.5 g (child less that 12 years:
30 mg/kg up to 1.5 g) IV by slow infusion (over at least 60 minutes; rate not
exceeding 10 mg/min), ending the
infusion just before the procedure
OR
teicoplanin 400 mg (child: 10 mg/kg up to 400 mg) IV, just
before the procedure
OR
teicoplanin 400 mg (child: 10 mg/kg up to 400 mg) IM, 30
minutes before the procedure.
There is no oral liquid formulation of clindamycin in
Australia. An alternative for patients
who are hypersensitive to penicillin (excluding immediate hypersensitivity),
is:
cephalexin 2 g (child: 50 mg/kg up to 2 g) orally, 1 hour
before the procedure.
Cephalexin is not suitable for those who have been on
long-term penicillin or have taken related beta-lactam antibiotic more than
once in the previous month.
NOTE: These
guidelines are those used at RCH, but may differ from recommendations at other
centres.
Reference: Infective
Endocarditis Prophylaxis Expert Group.
Prevention of endocarditis. 2008 update from Therapeutic
guidelines:
antibiotic version 13, and Therapeutic guidelines: oral and
dental version 1.
Melbourne:
Therapeutic Guidelines Limited; 2008.
http://www.tg.org.au/uploads/PDFs/Prevention%20of%20endocarditis.pdf
These guidelines are those currently endorsed by the Cardiac
Society of
Australia and New Zealand.