Acute management of an oesophageal variceal bleed

  • Introduction

    Oesophageal varices (and indeed any varices) are a rare but serious complication of portal hypertension. Portal hypertension is defined by an increase in pressure within the portal circulatory system and is  caused by an increase in vascular resistance in blood flow through the liver. In RCH’s patient population, portal hypertension is frequently a result of biliary atresia, but it can also be a manifestation of post-hepatic, pre-hepatic (e.g. portal vein obstruction), or other intra-hepatic problems such as cystic fibrosis, congenital hepatic fibrosis or other cirrhosis. With increased resistance in the portal vascular system, blood begins to shunt through collateral systemic vessels to return to the vena cava. Prolonged elevation in portal vein pressure causes dilatation of the collateral vessels, which can form internal varices in the rectum and varices in the gastro-oesophageal veins. Oesophageal variceal bleeds occur when the variceal wall tension exceeds the wall strength and subsequently rupture. Children with liver disease also have liver dysfunction, which results in clotting cascade problems and a deficit in Vitamin K-dependent factors. This increases the risk of significant haemorrhage in this patient group.

    In several large studies of children with portal hypertension, approximately two thirds presented with haematemesis (vomiting blood) or melaena (blood in stool/dark stools caused by upper GI bleeds), usually from rupture of an oesophageal varix. Twenty to thirty percent of children with biliary atresia have variceal bleeds and tend to develop varices early, with an estimated risk of bleeding of fifteen percent before the age of two. Mortality rates associated with large bleeds range from zero to fifteen percent.

    The aim of this guideline is to assist nurses and other health professionals in the management of infants and children with oesophageal varices to minimise risk of variceal bleeding. This guideline will also outline the management of an acute oesophageal variceal bleed. 

    Definition of Terms

    • GI - gastrointestinal
    • NGT – Nasogastric tube
    • PPIs – Proton pump inhibitors (e.g., omeprazole, pantoprazole)

    Assessment of Patients with Known or Suspected Varices

    • Complete primary assessment as per Clinical Guidelines (Nursing) : Nursing assessment
    • Routine observations as per Clinical Guidelines (Nursing): Observation and Continuous Monitoring
    • Monitor for signs of hypovolaemia: e.g. tachycardia, hypotension.
    • Investigations: FBE, UEC, VBG, Coagulation Screen, Group & hold, blood cultures, BGL, ammonia, see specimen collection.
    • Monitor for upper GI bleeding (e.g. haematemesis or coffee ground vomit)
    • Monitor for melaena or fresh blood in stools.
    • Capture clinical images of melaena & haematemesis to guide volumes of blood loss.
    • Monitor for abdominal distension or protruding umbilical veins, especially when seen in combination with other listed symptoms.
    • Assess coagulation screen for risk of bleeding.
    • Maintain strict fluid balance including measurement or estimation of losses, including urine output.
    • Monitor for neurological changes.

    Management of Children with Known or Suspected Varices

    • NGT insertion should be carried out with caution in patients with known or suspected varices. Refer to Enteral Feeding and Medication Administration Guideline.
      • Stylet should be removed.
      • Insertion should be carried out by senior staff members or medical personnel in high-risk patients. Eg those who have had previous GI bleeds, those with significant coagulopathies, those with high grades varices as identified by treating team.
      • NGT should not have a gastric aspirate taken from the tube. Instead, position should be confirmed by x-ray.
    • Ensure patient has valid blood product consent on file (see RCH Consent- Informed Procedure)
    • Family should be provided with education on varices and at home emergency management plan by Liver & Intestinal Transplant Clinical Nurses Consultants or Gastroenterology team members.
    • Patients should have routine surveillance gastroscopies to monitor status and progression of varices. Banding or sclerotherapy can be undertaken as required. Frequency of gastroscopies is dictated by treating gastroenterologist.
    • Patients should have the following investigations prior to gastroscopies: FBE, UEC, coagulation screen, group & hold. 

    Acute Management of Variceal Bleed (refer to algorithm overleaf)

    •  Seek urgent medical/ ICU review/ MET (ext. 2222).
    • Protect airway, support breathing as required (see Resuscitation guidelines). Give oxygen to patients with significant circulatory impairment or shock.
    • Secure large bore IV access.
    • Consider need to activate RCH Massive Haemorrhage and Critical Bleeding Procedure.
    • Correct hypovolaemia, remembering the potential for harm with excessive fluid administration
      • No more than 20mL/kg NaCl bolus. Albumin should also be given if further fluid administration is required. 
      • RBCs if Hb <70g/L.
    • Maintain strict fluid balance.
    • Consider vasoactive therapy:
      • Octreotide, IV bolus followed by IV infusion. Refer to Medication Guideline: Octreotide for dosing
      • Always discuss with a gastroenterology fellow or consultant before commencing vasoactive therapy.
      • Once bleeding controlled, slow wean of octreotide as per Octreotide Medication Guideline
      • Monitor BGL 6 hourly whilst on octreotide infusion due to risk of hypoglycaemia and/or hyperglycaemia – escalate any abnormal results to treating team
    • Continuous cardiorespiratory monitoring (see Clinical Guidelines (Nursing): Observation and Continuous Monitoring).
    • If NGT in situ, place on free drainage. Do NOT aspirate NGT. NGT should only be inserted under endoscopic guidance or with gastroenterologist consent.
    • Consider treating coagulopathies (vitamin K, platelets, cryoprecipitate and FFP).
    • If bleeding is ongoing and uncontrollable, patient will require Balloon Tamponade (Foleys Catheter if child <15kg or Sengstaken Blakemore tube if child>15kg). This will ideally be performed in the ICU or theatre environment.
    • Transfer to ICU or theatre for management as clinically appropriate
    • Consider prophylactic intravenous antibiotics.
    • Patient should be kept nil by mouth (NBM) until bleeding controlled and medically cleared for oral intake.
    • Whilst NBM, all regular medications should be given IV.
    • Consider use of PPI: IV whilst NBM followed by oral once cleared for oral intake.

    Management of Patients with Recent Variceal Bleeding/Banding

    • Patients should remain nil by mouth (NBM) post variceal bleeding or banding and grade up diet as directed by treating gastroenterologist.
    • Ensure patient has a valid group and hold in case requires transfusion.
    • Maintain IV access.
    • Ensure foley catheter is at bedside in case of re-bleed. If leaving the ward, patient must take catheter with them.

    Special considerations

    Algorithm for Management of Acute Variceal Bleed

    Acute Variceal Bleed 2023

    Links

    Clinician websites

    Information for parents

    *Please remember to read the disclaimer.

    The development of this nursing guideline was coordinated by Rachel Horn, CNC, Gastroenterology, and Laura Davies, CNS, Cockatoo, approved by the Nursing Clinical Effectiveness Committee. Updated December 2023.  

    Evidence table

    Reference  

    Source of evidence

    Key findings and considerations 
     Afaa, T. J., Amegan-Aho, K. H., Richardson, E., & Goka, B. (2020). Diagnosis and management of extrahepatic oesophageal variceal bleed in children in a low resourced setting. Ghana medical journal, 54(4), 274–278. https://doi.org/10.4314/gmj.v54i4.11  Cohort study
    • Dosing guide on Octreotide: The dose of octreotide is 1–5 µg/Kg by bolus over 20 minutes, followed by continuous infusion at 2 µg/Kg/h and should be continued for 2–5 days. 
    Attard, T.M., Miller, M., Pant, C. & Thomson, M. (2017). Readmission after Gastrointestinal Bleeding in Children: A Retrospective Cohort Study. Journal of Pediatrics. May 2017, 184:106-113.e4 DOI10.1016/j.jpeds.2017.01.044
    Cohort study
    • Retrospective review of treatment of gastrointestinal bleeding and subsequent rates of re-bleed/readmission 
    • Discussed treatments including endoscopy, sclerotherapy and proton pump inhibitors.
    Chiou. F.K. & Abdel-Hady, M. (2017). Portal hypertension in children. Paediatrics and Child Health, December 2017 27(12): 540-545.

    Systematic review
    • The authors outline possible clinical presentations and treatments for major complications arising from portal hypertension, including gastrointestinal and variceal bleeds.  
    • Outlined management options relating to a bleed: Intravenous fluid resuscitation, crystalloid fluids, Red blood cell transfusion (target haemoglobin of 70–80 g/L), Nil by mouth, nasogastric tube on free drainage, correct coagulopathy (Vitamin K, fresh frozen plasma) and thrombocytopenia (if less than 20 × 10 9 /L), empiric broad-spectrum antibiotics,  
    • Recommended monitoring vital signs, urine output, conscious level, blood sugar and haemoglobin levels,  
    • Dosing of IV Octreotide: 1–5 mcg/kg/hour continuous infusion,  
    • Dosing of IV Omeprazole: 1 mg/kg/dose od, or IV Ranitidine 1–3 mg/kg/dose tds 
      D’Antiga, L. (2012). Medical management of esophageal varices and portal hypertension in children. Seminars in Pediatric Surgery, August 2012, 21(3): 211-218.
      Review
      • The paper recommends the following, regarding management of acute variceal bleeding: Monitor vital signs, obtain venous access, FBC, INR, LFTs, UECs, crossmatch. PRBCs to maintain Hb 7g/dL, carefully avoiding a rebound fluid overload which would lead to rebleeding.
      Duche, M., Ducot, B., Ackermann, O., Guerin, F., Jacquemin, E. & Bernard, O. (2017). Portal hypertension in children: High-risk varices, primary prophylaxis and consequences of bleeding. Journal of Hepatology, February 2017, 66(2): 320- 327.

       Retrospective cohort study 
      • Compared efficacy of primary surgical or endoscopic prophylaxis in children with portal hypertensio
      • Discussed common causes of gastrointestinal bleeding in children and pathophysiology of portal hypertension 
      • The authors thus concluded that prevention of the first bleed in children with high-risk varices can be achieved by surgery or endoscopic treatment, and decreases mortality and morbidity


        Giouleme, O. & Theocharidou, E. (2013). Management of Portal Hypertension in Children With Portal Vein Thrombosis. Journal of Pediatric Gastroenterological Nutrition, October 2013, 57(4): 419-425. DOI: 10.1097/MPG.0b013e3182a1c d7f 



        Systematic review
        • Describes portal vein thrombosis aetiology, clinical presentation, diagnosis, and treatment of portal hypertension, including pharmacologic, endoscopic and surgical options.  
        • PVT is a common cause of PH, variceal bleeding and splenomegaly are the two most common initial manifestations (p419).  
        • Extrahepatic portal vein obstruction (EHPVO) is a major cause of PH in children (419).  
        • Oesophageal varices are present in 90-95% of patients with PVT, with PV occlusion leading to vasodilation of the hepatic artery and formation of collateral vessels (419) Anorectal varices are also common.  
        • The use of non-selective beta-blockers to prevent variceal bleeding in adults is established and comparable to EVL. Some small case-series paediatric studies have been undertaken (421).  
        • In the setting of an acute variceal bleed event, beta blockers may inhibit the protective effect of tachycardia - a crucial compensatory mechanism for shock in children (421).  
        • Vasoactive agents such as vasopressin and somatostatin induce splanchnic vasoconstriction, thereby decreasing portal venous inflow (421)  
        • Sclerotherapy and EVL are highly effective in paediatric variceal bleed management (422). 
        Gugig, R. & Rosenthal, P. (2012). Management of portal hypertension in children. World Journal of Gastroenterology. 18(11):1176-1184. DOI: 10.3748/wjg.v18.i11.1176  Systematic review
        • Describing the best practice management of portal hypertension in children, including primary and secondary prophylaxis, Emergency therapy of variceal bleeding, Pharmacology, Endoscopy, Sengstaken-Blackmore tubes Surgical and interventional radiology and Sclerotherapy and ligation therapy. While the evidence in the paper is now outdated, practice remains unchanged, as far as can be determined.  
        • The initial management of variceal bleeding is stabilization of the patient. Patients on beta blocker therapy may not manifest the usual compensatory tachycardia and are at higher risk of developing significant hypotension.
        • Conservative fluid resuscitation in the form of crystalloid initially, followed by red blood cell transfusion, is critical to avoid overfilling the intravascular space and increasing portal pressure. 
        • Platelets should be administered for levels less than 50 × 109/L, and coagulopathy corrected with vitamin K and fresh frozen plasma. There may be a value to the use of recombinant factor VIIa in severe coagulopathy as the fluid requirements may be diminished.  
        • Intravenous antibiotic therapy should be considered for all patients with variceal bleeding in light of the high risk of potentially fatal infectious complications. Once the patient is stabilized, endoscopy should be performed to document that haemorrhage is indeed from variceal rupture.
        • The Sengstaken-Blackmore tube (SSBT) was designed to stop hemorrhage by mechanically compressing esophageal and gastric varices. The device consists of a rubber tube with at least two balloons. It is passed into the stomach, where the first balloon is inflated and pulled up snug against the gastroesophageal junction. Once the tube is secured in place, the second balloon is inflated in the esophagus at a pressure (60-70 mmHg) that compresses the varices without necrosing the esophagus. A channel in the rubber tube allows gastric contents to be sampled for evidence of bleeding. This therapy is very effective in controlling acute bleeding but is associated with significant number of complications and high incidence of re-bleeding when the tube is removed.  
        • Its use in children requires significant sedation. Use of the SSBT increases the risk of aspiration pneumonia, which can be a life threatening complication in a patient with liver failure. 
        • Re-bleeding has been reported in 33%-60% of patients. Given these problems it is reserved for severe uncontrollable haemorrhage and generally serves as a temporizing measure until a more definite procedure can be performed.
          Hussey, S., Kelleher, K.T. & Ling, S. (2010). Emergency Management of Major Upper Gastrointestinal Hemorrhage in Children. Clinical Pediatric Emergency Medicine, September 2010; 11(3): 207- 216.
          Systematic review 
          • This paper makes recommendations for the acute management of major upper intestinal bleed in children, including securing the airway, obtaining IV access, blood investigations, fluid resuscitation; pharmacological therapies (treatment of coagulopathies, acid suppression, somatostatin analogues and antibiotics) and subsequent management with endoscopy and surgery.  
          • The paper contains a useful algorithm (p209) for management of a patient with a significant GI bleed in children, which is comparable to the algorithm in the RCH Clinical Guideline.  
          • Determine the presence of shock and haemodynamic instability (p208)  
          • Support for and reestablishment of an effective circulating volume is a resuscitation priority (p208) – recommend 20ml/kg NaCl bolus then blood products  
          • At cannulation, obtain Group & Hold and crossmatch, FBE, coags, LFTs, albumin, UECs, blood gas and lactate, BCs (p210) Vitamin K could be administered empirically and INR corrected with FFP (p212)   
          • The use of PPIs is not without controversy, given they require liver metabolism, however no paediatric data available to suggest they are unsafe (p212).  
          • Whether bacterial translocation occurs as sequela or plays a role in pathogenesis of haemorrhage is unclear. Usual choice of antibiotics is ampicillin and cefotaxime (p212). 
          • Somatostatin analogues (eg octreotide, 1-2mcg/kg bolus followed by 1-5mcg/kg/hr). 
            Koul, P.B., Totapally, B.R. & Raszynski, A. (2012). Continuous octreotide infusion for treatment of upper gastrointestinal bleeding due to portal hypertension in children: An observational study from pediatric intensive care unit. Journal of Pediatric Intensive Care. 01(02): 099- 103. DOI: 10.3233/PIC-2012- 017
            Cohort study
            • Evaluated the use of octreotide for the control of acute upper gastrointestinal bleeding in children with portal hypertension.  
            • Seven of the 13 children reviewed received a loading dose (1.27 ± 0.76 µg/kg), and the remaining five children received a median starting dose of 1.44 ± 1.19 µg/kg/h. The mean maximum dose was 1.68 ± 1.38 µg/kg/h.  
            • Re-bleeding occurred in one third; hemostasis was eventually achieved in all. 
            • The study found that octreotide infusion appears to be safe and effective in controlling pediatric upper gastrointestinal bleeding due to portal hypertension.
               Mileti, E. & Rosenthal, P. (2011). Management of portal hypertension in children. Current Gastroenterology Reports. 13(1): 10-16.
                
              • Pathophysiology of portal hypertension and makes recommendations for the prevention and management of variceal bleeding in children.
              • The paper provides some useful discussion on balloon tamponade and complications: “The length of the esophageal balloon limits the use of the Minnesota and Sengstaken-Blakemore tubes to children weighing more than 40kg.” “Bleeding can be stopped in almost 90% of cases by balloon tamponade; however, the tubes are only temporizing measures and cannot be kept in place for more than 24h [9]. “
              • Tube placement should be attempted only by individuals who have been trained and are comfortable with their use, because complication rates are high when the tubes are not properly placed.
              • Complications include esophageal perforation, aspiration, mucosal ischemia, and airway obstruction [9,10].
              • When balloon tamponade is required, there should be a low threshold for intubation, and intubation is highly recommended.

              Pimenta, J.R., Ferreira, A.R., Fagundes, E., Queiroz, T., Baptista, R. de Araújo Moreira, E.G., de Resende, C.B., Bittencourt, P., Carvalho, S.D., Neto, J. & Penna, F.J. (2017). Factors Associated With Bleeding Secondary to Rupture of Esophageal Varices in Children and Adolescents With Cirrhosis. Journal of Pediatric Gastroenterology and Nutrition. February, 64(2): e44–e48 

              Retrospective cohort study 
              • This cross-sectional single centre study included 103 children and adolescents diagnosed with PHT and liver cirrhosis.  
              • The most prevalent diagnoses in the study group were biliary atresia (33%), and autoimmune hepatitis (32%).  
              • Patients with BA who had an UGIB had the bleed at a median age of 2.9 years. The autoimmune hepatitis group with UGIB had the bleed at median age 8.4 years (e46). The study found that statistically significant risk factors for UGIB include the presence of red spots on varices and the presence of gastric varices, consistent with other studies identified by the study authors (e47).
              Singhi, S., Jain, P., Jayashree, M. & Lal, S. (2013); Approach to a child with upper gastrointestinal bleeding. Indian Journal of Pediatrics, April 2013; 80(4): 326-333.
              Symposium 
              • It describes the more frequent aetiologies of GI bleeding in Indian children and treatment and management pathways for these children.  
              • The paper contains a useful algorithm (p328) for management of a patient with a significant GI bleed, which is comparable to the algorithm in the RCH Clinical Guideline. 
              Vogel, C.B. (2-17). Pediatric portal hypertension: A review for primary care. The Nurse Practitioner, 12 May 201742(5): 35–42. DOI: 10.1097/01.NPR.0000515427. 91649.91
              Systematic review
              • This review paper outlines primary care requirements for health practitioners to consider, when caring for children with portal hypertension.  
              • It describes aetiology of disease, pathophysiology, clinical presentation, diagnostics, primary, secondary and tertiary treatment and management, including clinical pathways for referral if complications arise.  
              • Complications discussed in the paper include haemorrhage from varices, ascites, hepato-pulmonary syndrome, porto-pulmonary hypertension, and hepatic encephalopathy (p39).  
              • Variceal bleeding is the most serious complication of portal hypertension, which can occur from venous collaterals in the stomach or oesophagus. Varices and ascites are seen when portal pressure is 12 mm Hg or greater. This is not a subtle finding, as there is a 30% mortality with variceal bleeding (p 39). Acute management strategies listed in the paper include: octreotide, PPIs, PRBCs and/or platelets, and endoscopy. 

              Wanty, C.,Helleputte, T., Smets, F., Sokal, E.M. & Stephenne, X. (2013). Assessment of risk of bleeding from esophageal varices during management of biliary atresia in children. Journal of Pediatric Gastroenterology and Nutrition, 56(5): 537–543. DOI:10.1097/MPG.0b013e318 282a22c 

              Retrospective review  
              • This retrospective study reviewed clinical, ultrasonographic, endoscopic, and laboratory data of 83 patients with biliary atresia from the beginning of medical management up to the occurrence of an upper gastrointestinal bleeding event.
              • The researchers found that 20% of the patients had a gastrointestinal bleed incident, with a median age of 9.5 months (6-50 months).