First line: FBE, PT/INR, APTT, Fg

Second line: LFTs, U&E, Creatinine, Calcium, VWD screen with blood group, Factor VIII and IX levels

Additional investigations are sometimes warranted and should be discussed with VFPMS and/or haematologist as appropriate

Calcium, Phosphate, Magnesium, Alkaline Phosphatase, PTH, LFTs, U&E, Creatinine

Consider:

25OH Vitamin D if child <6months or suspicion of rickets

Septic work-up and inflammatory markers if possible osteomyelitis

Copper and ceruloplasmin levels if child at risk for copper deficiency

Vitamin C level (contact pathology staff to ensure adequate sample is provided) if child at risk of scurvy

Syphilis serology in the presence of subperiosteal new bone formation or any other suggestive clinical signs

Genetic testing for Osteogenesis Imperfecta (OI) or connective tissue disease if clinically indicated

Intracranial bleeding (suspected AHT)

FBE, INR, APTT, Fg, LFTs, U&E, Creatinine, Calcium, VWD screen with blood group, Factor VIII and IX levels

Radiological investigations as appropriate:

CT Scan Brain +/- MRI brain and spine if acute neurologic symptoms. NB STIR sequences on MRI to detect cervical ligamentous injury

Non-urgent MRI Brain and whole spine if no symptoms

Amylase, lipase, LFTs, Urine dipstick, FBE, Fg

Radiological investigations as indicated

Abdominal CT Scan should be obtained if:

Possible paralytic ileus (absent/hypoactive bowel sounds)

Possible intra-abdominal haemorrhage

Significantly abnormal laboratory result (for example ALT or AST >80IU/L)

≥2 abnormal laboratory results